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Here are the biggest calls on Wall Street on Wednesday

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Boeing Co reported a nearly $3 billion second-quarter loss on Wednesday as the world's largest planemaker struggles with the prolonged grounding of its best-selling 737 MAX jet, sending its shares down 1% in premarket trading.

Anthem Inc shares fell as much as 4% on Wednesday after the U.S. health insurer missed Wall Street expectations for a key medical cost gauge as a result of higher costs of selling Medicaid health plans for low-income customers.

Caterpillar Inc's on Wednesday reported lower quarterly earnings, hurt by cooling demand for construction machines in Asia-Pacific as well as weak sales at its energy and transportation division.

Dunkin' Brands Group Inc said on Wednesday it would add vegan burger maker Beyond Meat Inc's plant-based sausages to its breakfast menu at stores in Manhattan.

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United Parcel Service Inc on Wednesday said demand for its Next Day Air and Ground services drove better-than-expected quarterly profit as large retailers rushed packages to online shoppers.

U.S. stocks opened lower on Wednesday after bleak earnings from bellwethers Caterpillar and Boeing exacerbated concerns over slowing global growth.

General Motors Co's self-driving unit, Cruise, said on Wednesday it was delaying the commercial deployment of cars past its target of 2019 as more testing of the vehicles was required.

Boeing Co reported a nearly $3 billion quarterly loss on Wednesday, its largest in a decade, as the world's largest planemaker struggles with the prolonged grounding of its best-selling 737 MAX jet, sending its shares down slightly in premarket trading.

Facebook Inc will pay a record-breaking $5 billion fine to resolve a government probe into its privacy practices and the social media giant will restructure its approach to privacy, the U.S. Federal Trade Commission said on Wednesday.

Deutsche Bank reported a bigger than forecast quarterly loss of 3.15 billion euros ($3.5 billion), underlining the challenges faced by Chief Executive Christian Sewing as he attempts to turn around the struggling business.

The "very best thing" that can happen to investors in their 20s, 30s and early 40s is another 10-year period of no returns in the S&P 500, expert Josh Brown says.

Caterpillar Inc's earnings on Wednesday missed Wall Street's estimates, hurt by a combination of weak sales in China, and higher production and restructuring costs, leading to a nearly 4% fall in its shares in premarket trade.